NPTX1

Across TCGA patient cohorts, NPTX1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPTX1-associated genes across cancer lineages are Notch1, ATM, and eEF2. Each is linked with NPTX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPTX1-to-partner and partner-to-NPTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by NPTX1-low versus NPTX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPTX1→partner) and Y-score (partner→NPTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.189	+3.000	.001	.001	3	2
UCEC	ATM →	-0.541	-2.321	.003	.006	3	2
UCEC	eEF2 →	+0.397	+3.169	.007	.018	3	1
UCEC	EGFR_pY1068 →	-0.287	-2.321	.005	.006	3	1
UCEC	eIF4E →	+0.225	+2.321	.009	.006	2	2
UCEC	eIF4G →	+0.292	+2.999	.023	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Notch1 by NPTX1 expression — UCEC

Explore this box plot interactively →