NPTX1

Across TCGA pan-cancer cohorts, NPTX1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NPTX1 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher NPTX1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NPTX1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and CHOL show a favorable association.

KIRP, UVM, and ACC are the cancer types where NPTX1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.537	0.823	<.001	130	view →
UVM	DFS	Median	All	0.422	0.757	<.001	89	view →
ACC	DFS	Median	All	0.240	0.645	<.001	86	view →
BLCA	OS	Median	All	0.349	0.522	.002	72	view →
THCA	OS	Quartile	II,III,IV	0.714	1.000	.002	51	view →
LUSC	DFS	Median	III,IV	0.208	0.534	<.001	41	view →
MESO	OS	Median	III,IV	0.416	0.730	<.001	38	view →
BRCA	DFS	Median	All	0.969	0.928	<.001	36	view →
STAD	OS	Tertile	II,III,IV	0.560	0.717	.005	33	view →
CHOL	OS	Tertile	II,III,IV	0.803	0.200	.004	27	view →
READ	DFS	Tertile	II,III,IV	0.612	0.944	.013	19	view →
ESCA	OS	Median	All	1.000	0.427	.007	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NPTX1–KIRP (OS)

Open the KIRP breakdown →