NPTX1

Across TCGA cell cohorts, NPTX1 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPTX1-associated genes across cancer lineages are R3HDML, DMRTC2, and F13B. Each is linked with NPTX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPTX1-to-partner and partner-to-NPTX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HDML grouped by NPTX1-low versus NPTX1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPTX1→partner) and Y-score (partner→NPTX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	2
SKIN	DMRTC2 →	+0.096	+5.415	<.001	.004	3	1
LARGE_INTESTINE	F13B →	+0.078	+4.035	<.001	<.001	3	1
LARGE_INTESTINE	FCN2 →	+0.025	+3.678	<.001	.001	3	1
LARGE_INTESTINE	SPEM2 →	+0.045	+2.989	.002	.003	3	1
LARGE_INTESTINE	PAX2 →	+0.472	+3.404	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

R3HDML by NPTX1 expression — BLOOD_Lymphoma

Explore this box plot interactively →