NPRL3

Across TCGA pan-cancer cohorts, NPRL3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NPRL3 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NPRL3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NPRL3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where NPRL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.888	.003	26	view →
PDAC	OS	Quartile	II,III,IV	0.711	0.348	.007	21	view →
HNSC	DFS	Median	III,IV	0.935	1.000	.039	2	view →
LSCC	OS	Median	All	0.937	0.801	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NPRL3–CCRCC (OS)

Open the CCRCC breakdown →