NPRL3

Across TCGA pan-cancer cohorts, NPRL3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NPRL3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPRL3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPRL3 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where NPRL3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPRL3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.615	<.001	12	view →
COAD	All	IV	+1.611	<.001	11	view →
KIRP	Male	II,III,IV	+0.919	<.001	11	view →
STAD	Male	II,III,IV	+1.207	<.001	10	view →
LIHC	Female	II,III,IV	+1.157	<.001	9	view →
HNSC	Male	All	+0.525	<.001	9	view →
THCA	All	All	−0.167	.004	7	view →
LUSC	Male	II,III,IV	+0.708	<.001	6	view →
BRCA	All	III,IV	+0.408	<.001	6	view →
CHOL	Female	All	+2.476	<.001	5	view →
KICH	Male	IV	+0.949	<.001	5	view →
READ	All	All	+0.942	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NPRL3–KIRC

Open the KIRC breakdown →