NPRL3

Across TCGA patient cohorts, NPRL3 mutation is significantly associated with the RNA expression of many other genes, with 559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPRL3-associated genes across cancer lineages are TTTY7B, PRF1, and RPL23AP82. Each is linked with NPRL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPRL3-to-partner and partner-to-NPRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTTY7B grouped by NPRL3-low versus NPRL3-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPRL3→partner) and Y-score (partner→NPRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TTTY7B →	+0.024	+8.471	<.001	.005	3	2
UCEC	PRF1 →	+0.933	+1.928	.002	.009	3	2
UCEC	RPL23AP82 →	+0.405	+2.708	.001	.003	3	2
UCEC	NDUFA6 →	+0.464	+3.343	<.001	.005	3	2
UCEC	MIR7-2 →	+0.186	+2.714	<.001	.004	3	2
UCEC	SYPL1P1 →	+0.130	+2.316	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 559 associations by consensus.

TTTY7B by NPRL3 expression — BRCA

Explore this box plot interactively →