NPRL3

Across TCGA patient cohorts, NPRL3 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPRL3-associated genes across cancer lineages are Annexin-1, PCNA, and ERK2. Each is linked with NPRL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPRL3-to-partner and partner-to-NPRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by NPRL3-low versus NPRL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPRL3→partner) and Y-score (partner→NPRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.460	+2.189	.045	.034	3	2
COAD	PCNA →	+0.271	+2.815	.046	.036	3	2
UCEC	ERK2 →	+0.193	+2.999	.022	.035	3	1
UCEC	HER3 →	+0.376	+3.013	.001	.018	3	1
UCEC	MEK1 →	+0.426	+3.459	.007	.005	3	1
UCEC	MSH6 →	-0.473	-3.321	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Annexin-1 by NPRL3 expression — UCEC

Explore this box plot interactively →