NPRL3

Across TCGA cell cohorts, NPRL3 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NPRL3-associated genes across cancer lineages are TBC1D21, FAM153B, and TAFA1. Each is linked with NPRL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPRL3-to-partner and partner-to-NPRL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by NPRL3-low versus NPRL3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPRL3→partner) and Y-score (partner→NPRL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	FAM153B →	+0.541	+3.618	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	GMCL2 →	+0.050	+3.428	<.001	.008	3	1
BLOOD_Leukemia	BMP5 →	+0.012	+3.771	<.001	.004	3	1
BLOOD_Leukemia	C20orf85 →	+0.027	+3.969	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

TBC1D21 by NPRL3 expression — LARGE_INTESTINE

Explore this box plot interactively →