NPRL2

Across TCGA patient cohorts, NPRL2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,513 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NPRL2-associated genes across cancer lineages are RPTOR, MLXIP, and OR51E1. Each is linked with NPRL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPRL2-to-partner and partner-to-NPRL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPRL2 versus RPTOR in LSCC, with a Pearson correlation of -0.24.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPRL2→partner) and Y-score (partner→NPRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RPTOR →	-0.411	-0.142	<.001	.003	3	3
BRCA	MLXIP →	-0.611	-0.297	<.001	<.001	3	3
GBM	OR51E1 →	-0.586	-0.207	.006	.002	3	3
LSCC	ANAPC7 →	-0.454	-0.188	<.001	<.001	3	3
GBM	TXNIP →	+0.660	+0.209	<.001	.001	3	3
OV	GET3 →	-0.461	-0.658	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,513 associations by consensus.

NPRL2 vs RPTOR — LSCC

Explore this scatter interactively →