NPRL2

Across TCGA pan-cancer cohorts, NPRL2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated NPRL2 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher NPRL2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPRL2 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

KICH, ACC, and UVM are the cancer types where NPRL2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	III,IV	0.241	0.951	<.001	91	view →
ACC	DFS	Tertile	All	0.140	0.632	<.001	72	view →
UVM	OS	Median	All	0.800	0.406	.001	56	view →
KIRP	DFS	Median	II,III,IV	0.878	0.641	.001	53	view →
LIHC	DFS	Tertile	All	0.372	0.532	<.001	51	view →
LUAD	OS	Tertile	All	0.867	0.765	.002	26	view →
BRCA	OS	Median	All	0.947	0.902	.002	25	view →
OV	DFS	Tertile	II,III,IV	0.586	0.472	.023	24	view →
THYM	OS	Median	All	1.000	0.921	.012	19	view →
KIRC	DFS	Quartile	II,III,IV	0.357	0.658	.001	18	view →
PRAD	DFS	Quartile	All	0.885	0.959	.010	14	view →
CESC	DFS	Median	IV	0.263	0.684	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

NPRL2–KICH (DFS)

Open the KICH breakdown →