NPRL2

Across TCGA patient cohorts, NPRL2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPRL2-associated genes across cancer lineages are EGFR_pY1068, p62 Lck ligand, and PDK1_pS241. Each is linked with NPRL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPRL2-to-partner and partner-to-NPRL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by NPRL2-low versus NPRL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPRL2→partner) and Y-score (partner→NPRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.258	-2.321	.041	.035	3	1
UCEC	p62 Lck ligand →	+0.388	+3.459	.017	.005	3	1
UCEC	PDK1_pS241 →	+0.304	+3.169	<.001	.019	3	1
UCEC	AMPK_pT172 →	+0.462	+2.335	.025	.020	3	1
UCEC	Tuberin_pT1462 →	+0.258	+2.321	.026	.035	3	1
UCEC	Tuberin →	+0.367	+2.817	.006	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by NPRL2 expression — UCEC

Explore this box plot interactively →