NPRL2

Across TCGA cell cohorts, NPRL2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NPRL2-associated genes across cancer lineages are TGM6, UBQLN3, and TEX44. Each is linked with NPRL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPRL2-to-partner and partner-to-NPRL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM6 grouped by NPRL2-low versus NPRL2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPRL2→partner) and Y-score (partner→NPRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TGM6 →	+0.006	+4.807	<.001	.006	3	1
SKIN	UBQLN3 →	+0.012	+4.415	<.001	.007	3	1
SKIN	TEX44 →	+0.040	+4.467	<.001	.004	3	1
SKIN	OPN1MW →	+0.027	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TGM6 by NPRL2 expression — BLOOD_Myeloma

Explore this box plot interactively →