NPR2

Across TCGA patient cohorts, NPR2 mutation is significantly associated with the RNA expression of many other genes, with 4,674 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPR2-associated genes across cancer lineages are ASF1B, EMC7, and TIMM29. Each is linked with NPR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPR2-to-partner and partner-to-NPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASF1B grouped by NPR2-low versus NPR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR2→partner) and Y-score (partner→NPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASF1B →	+0.495	+2.055	.002	<.001	3	4
UCEC	EMC7 →	+0.455	+2.076	<.001	<.001	3	4
UCEC	TIMM29 →	+0.324	+1.653	<.001	<.001	3	4
COAD	UFD1 →	+0.411	+2.598	<.001	.006	3	4
COAD	ANKRD39 →	+0.308	+3.200	.008	.009	3	3
COAD	RAET1K →	+0.604	+3.469	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,674 associations by consensus.

ASF1B by NPR2 expression — UCEC

Explore this box plot interactively →