NPR2

Across TCGA patient cohorts, NPR2 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPR2-associated genes across cancer lineages are STAT3_pY705, JNK_pT183_Y185, and GAPDH. Each is linked with NPR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPR2-to-partner and partner-to-NPR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by NPR2-low versus NPR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPR2→partner) and Y-score (partner→NPR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.204	-1.311	.010	.027	3	4
SKCM	JNK_pT183_Y185 →	-0.134	-2.321	.048	.035	3	2
COAD	GAPDH →	+0.863	+3.012	<.001	.018	3	2
UCEC	MEK1 →	+0.370	+3.087	<.001	<.001	3	2
COAD	Cyclin-B1 →	+0.603	+2.824	.024	.034	3	2
UCEC	eIF4E →	+0.164	+2.247	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

STAT3_pY705 by NPR2 expression — UCEC

Explore this box plot interactively →