NPPC

Across TCGA patient cohorts, NPPC RNA expression is significantly associated with the protein abundance of many other proteins, with 8,646 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible NPPC-associated proteins across cancer lineages are TRIM24, BCL11A_S432, and BCL11A_S86. Each is linked with NPPC in more than 2 cancer types. Because this analysis shows association rather than direction, both NPPC-to-partner and partner-to-NPPC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPPC versus TRIM24 in HNSC, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NPPC→partner) and Y-score (partner→NPPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIM24 →	+0.256	+0.572	<.001	.001	3	3
HNSC	BCL11A_S432 →	+0.988	+1.535	<.001	<.001	3	3
LSCC	BCL11A_S86 →	+1.458	+1.728	<.001	.001	3	3
HNSC	AHNAK2_S4710 →	-0.742	-0.633	<.001	<.001	3	3
HNSC	ANXA2_T19 →	-0.543	-1.197	<.001	<.001	3	3
HNSC	MAP3K20_S727 →	-0.464	-0.798	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,646 associations by consensus.

NPPC vs TRIM24 — HNSC

Explore this scatter interactively →