NPPC

Across TCGA pan-cancer cohorts, NPPC RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NPPC data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NPPC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPPC expression acts as an unfavorable survival marker, although some lineages such as LUSC and CHOL show a favorable association.

ACC, UCEC, and UVM are the cancer types where NPPC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.259	0.615	<.001	90	view →
UCEC	OS	Quartile	IV	0.445	0.865	.002	74	view →
UVM	DFS	Quartile	II,III,IV	0.534	0.802	.003	63	view →
LUSC	OS	Quartile	All	0.736	0.553	<.001	53	view →
SCLC	OS	Quartile	All	0.305	0.590	.009	40	view →
LIHC	DFS	Tertile	II,III,IV	0.267	0.449	.007	38	view →
GBM	OS	Tertile	All	0.311	0.476	.004	26	view →
CHOL	OS	Median	All	0.775	0.413	.008	19	view →
BLCA	OS	Quartile	IV	0.188	0.624	.008	17	view →
SKCM	DFS	Quartile	IV	0.567	0.073	.017	12	view →
PAAD	OS	Median	II,III,IV	0.438	0.328	.021	9	view →
UCS	DFS	Median	II,III,IV	0.563	0.296	.020	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NPPC–ACC (DFS)

Open the ACC breakdown →