NPPC

Across TCGA cell cohorts, NPPC mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPPC-associated genes across cancer lineages are DEFA3. Each is linked with NPPC in more than 1 cancer types. Because this analysis shows association rather than direction, both NPPC-to-partner and partner-to-NPPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA3 grouped by NPPC-low versus NPPC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPPC→partner) and Y-score (partner→NPPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA3 →	+0.102	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

DEFA3 by NPPC expression — LARGE_INTESTINE

Explore this box plot interactively →