NPPB

Across TCGA patient cohorts, NPPB RNA expression is significantly associated with the go_rna of many other GO terms, with 6,824 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible NPPB-associated GO terms across cancer lineages are Protein hydroxylation, Mitochondrial gene expression, and Regulation of cell cycle G2/M phase transition. Each is linked with NPPB in more than 13 cancer types. Because this analysis shows association rather than direction, both NPPB-to-partner and partner-to-NPPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein hydroxylation grouped by NPPB-low versus NPPB-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPPB→partner) and Y-score (partner→NPPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Protein hydroxylation →	+0.049	+0.276	<.001	<.001	3	14
ESCA	Mitochondrial gene expression →	+0.066	+0.420	<.001	.002	3	13
STAD	Regulation of cell cycle G2/M phase transition →	+0.079	+0.303	<.001	<.001	3	13
STAD	Positive regulation of DNA metabolic process →	+0.075	+0.288	<.001	<.001	3	13
ESCA	Chaperone-mediated protein folding →	+0.064	+0.284	<.001	<.001	3	13
ESCA	Nucleoside triphosphate biosynthetic process →	+0.066	+0.355	<.001	.003	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,824 associations by consensus.

Protein hydroxylation by NPPB expression — ESCA

Explore this box plot interactively →