NPPB

Across TCGA pan-cancer cohorts, NPPB RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NPPB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NPPB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPPB is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

HNSC, BRCA, and KIRP are the cancer types where NPPB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPPB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.121	.019	5	view →
BRCA	All	II,III,IV	−0.049	.001	4	view →
KIRP	All	All	+0.373	.029	3	view →
UCEC	All	All	+0.507	.041	2	view →
UCEC	All	IV	−0.255	.003	2	view →
KICH	All	III,IV	−0.214	.023	2	view →
ESCA	All	II,III,IV	+0.085	.029	2	view →
PRAD	All	All	−0.036	.024	2	view →
LUSC	Female	III,IV	+0.140	.005	1	view →
READ	Female	All	−0.084	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

NPPB–HNSC

Open the HNSC breakdown →