NPPA-AS1

Across TCGA pan-cancer cohorts, NPPA-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated NPPA-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NPPA-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NPPA-AS1 expression acts as an unfavorable survival marker, although some lineages such as READ and UCEC show a favorable association.

ACC, READ, and LIHC are the cancer types where NPPA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.647	0.937	<.001	129	view →
READ	OS	Median	II,III,IV	0.860	0.476	<.001	58	view →
LIHC	OS	Quartile	II,III,IV	0.413	0.733	.001	30	view →
SKCM	DFS	Quartile	II,III,IV	0.401	0.649	.011	27	view →
LUSC	DFS	Tertile	II,III,IV	0.524	0.687	.010	25	view →
MESO	OS	Tertile	All	0.208	0.748	.002	21	view →
LGG	DFS	Quartile	All	0.677	0.824	.005	18	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
UCEC	DFS	Median	All	0.877	0.801	.008	18	view →
BRCA	OS	Quartile	III,IV	0.917	0.750	.007	17	view →
KIRC	DFS	Median	II,III,IV	0.365	0.622	.008	16	view →
CESC	OS	Quartile	III,IV	0.229	0.799	.027	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

NPPA-AS1–ACC (OS)

Open the ACC breakdown →