NPPA-AS1

Across TCGA pan-cancer cohorts, NPPA-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NPPA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NPPA-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NPPA-AS1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, LIHC, and BRCA are the cancer types where NPPA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPPA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.402	<.001	9	view →
LIHC	All	All	+0.312	<.001	7	view →
BRCA	Female	All	−0.310	<.001	6	view →
KIRC	All	All	+0.129	.006	6	view →
STAD	Male	II,III,IV	+0.632	.001	4	view →
LUSC	All	All	−0.460	<.001	4	view →
BLCA	Male	III,IV	+0.635	.028	2	view →
UCEC	All	II,III,IV	+0.439	.010	2	view →
LUAD	All	All	−0.319	.008	2	view →
PRAD	All	All	+0.292	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NPPA-AS1–KICH

Open the KICH breakdown →