NPM1P51

Across TCGA pan-cancer cohorts, NPM1P51 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NPM1P51’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where NPM1P51 RNA is repressed in tumor relative to normal tissue. In most cancer types NPM1P51 is over-expressed in tumor, although a few such as BRCA and PAAD show the opposite, repressed pattern.

BRCA, HNSC, and PAAD are the cancer types where NPM1P51 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPM1P51 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	All	−0.027	.022	4	view →
HNSC	All	III,IV	+0.060	.028	3	view →
PAAD	Female	All	−0.130	.049	2	view →
UCEC	All	All	−0.089	.032	2	view →
LUAD	All	All	+0.075	.009	1	view →
COAD	All	II,III,IV	+0.065	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NPM1P51–BRCA

Open the BRCA breakdown →