NPM1P42

Across TCGA patient cohorts, NPM1P42 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NPM1P42-associated genes across cancer lineages are SPEM1, MT-TD, and SNORD66. Each is linked with NPM1P42 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPM1P42-to-partner and partner-to-NPM1P42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPEM1 grouped by NPM1P42-low versus NPM1P42-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM1P42→partner) and Y-score (partner→NPM1P42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SPEM1 →	+0.172	+3.235	<.001	.005	3	1
SKCM	MT-TD →	+0.368	+4.356	<.001	.001	3	1
SKCM	SNORD66 →	+0.421	+3.783	<.001	.001	3	1
SKCM	RSU1P3 →	+0.038	+3.744	<.001	.003	3	1
SKCM	MIR920 →	+0.370	+3.302	<.001	.009	3	1
SKCM	ATG12P2 →	+0.259	+4.104	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

SPEM1 by NPM1P42 expression — SKCM

Explore this box plot interactively →