NPM1P42

Across TCGA pan-cancer cohorts, NPM1P42 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NPM1P42’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where NPM1P42 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPM1P42 is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

BRCA, KIRC, and READ are the cancer types where NPM1P42 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPM1P42 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	+0.035	.006	4	view →
KIRC	Male	II,III,IV	+0.044	.015	3	view →
READ	All	III,IV	+0.295	.030	2	view →
UCEC	All	All	−0.135	.031	2	view →
LUAD	Female	All	+0.063	.025	2	view →
THCA	All	III,IV	+0.061	.041	2	view →
LIHC	All	All	+0.021	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

NPM1P42–BRCA

Open the BRCA breakdown →