NPM1P1

Across TCGA patient cohorts, NPM1P1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,735 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NPM1P1-associated GO terms across cancer lineages are Ribosomal small subunit biogenesis, Maturation of SSU-rRNA, and rRNA metabolic process. Each is linked with NPM1P1 in more than 20 cancer types. Because this analysis shows association rather than direction, both NPM1P1-to-partner and partner-to-NPM1P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal small subunit biogenesis grouped by NPM1P1-low versus NPM1P1-high in LAML.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM1P1→partner) and Y-score (partner→NPM1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	Ribosomal small subunit biogenesis →	+0.046	+0.542	<.001	<.001	3	21
LAML	Maturation of SSU-rRNA →	+0.045	+0.393	<.001	<.001	3	20
STAD	rRNA metabolic process →	+0.033	+0.158	<.001	<.001	3	19
LAML	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.054	+0.395	<.001	<.001	3	19
LAML	Maturation of 5.8S rRNA →	+0.052	+0.404	<.001	<.001	3	19
STAD	Ribosome assembly →	+0.033	+0.133	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,735 associations by consensus.

Ribosomal small subunit biogenesis by NPM1P1 expression — LAML

Explore this box plot interactively →