NPM1P1

Across TCGA pan-cancer cohorts, NPM1P1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NPM1P1 data layer.

The strongest signal is observed in thymoma (THYM), where higher NPM1P1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPM1P1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LAML show a favorable association.

THYM, STAD, and LIHC are the cancer types where NPM1P1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Tertile	III,IV	0.363	0.913	.002	43	view →
STAD	OS	Median	III,IV	0.350	0.637	.004	40	view →
LIHC	DFS	Quartile	All	0.339	0.462	.002	39	view →
PAAD	OS	Tertile	All	0.219	0.437	.004	20	view →
LUAD	OS	Quartile	III,IV	0.292	0.611	.005	19	view →
LUSC	OS	Tertile	II,III,IV	0.557	0.298	<.001	19	view →
UCEC	DFS	Tertile	IV	0.228	0.563	.029	16	view →
COAD	DFS	Median	All	0.706	0.832	.003	15	view →
ESCA	DFS	Tertile	All	0.285	0.473	.030	12	view →
SKCM	DFS	Median	II,III,IV	0.175	0.287	.002	12	view →
HNSC	DFS	Tertile	All	0.344	0.348	.030	11	view →
LAML	DFS	Median	All	0.670	0.444	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NPM1P1–THYM (DFS)

Open the THYM breakdown →