NPM1

Across TCGA patient cohorts, NPM1 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,408 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NPM1-associated proteins across cancer lineages are GEMIN5, LARP1, and G3BP1. Each is linked with NPM1 in more than 8 cancer types. Because this analysis shows association rather than direction, both NPM1-to-partner and partner-to-NPM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NPM1 versus GEMIN5 in HNSC, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NPM1→partner) and Y-score (partner→NPM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GEMIN5 →	+0.294	+1.129	<.001	<.001	3	9
COAD	LARP1 →	+0.285	+0.581	<.001	<.001	3	8
LSCC	G3BP1 →	+0.275	+0.546	<.001	<.001	3	8
GBM	SRFBP1 →	+0.393	+0.372	<.001	<.001	3	7
OV	NOP16 →	+0.595	+0.794	<.001	<.001	3	7
CCRCC	BRIX1 →	+0.346	+0.465	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,408 associations by consensus.

NPM1 vs GEMIN5 — HNSC

Explore this scatter interactively →