NPLP1

Across TCGA patient cohorts, NPLP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,469 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NPLP1-associated GO terms across cancer lineages are Negative regulation of binding, Proton motive force-driven ATP synthesis, and Regulation of DNA binding. Each is linked with NPLP1 in more than 11 cancer types. Because this analysis shows association rather than direction, both NPLP1-to-partner and partner-to-NPLP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of binding grouped by NPLP1-low versus NPLP1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPLP1→partner) and Y-score (partner→NPLP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Negative regulation of binding →	+0.053	+0.325	<.001	<.001	3	12
STAD	Proton motive force-driven ATP synthesis →	+0.069	+0.293	<.001	<.001	3	12
STAD	Regulation of DNA binding →	+0.052	+0.347	<.001	<.001	3	11
ESCA	Protein complex oligomerization →	+0.045	+0.167	<.001	<.001	3	11
STAD	Membrane fusion →	+0.045	+0.351	<.001	<.001	3	11
STAD	Pyridine-containing compound metabolic process →	+0.042	+0.380	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,469 associations by consensus.

Negative regulation of binding by NPLP1 expression — STAD

Explore this box plot interactively →