NPL

Across TCGA pan-cancer cohorts, NPL mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NPL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NPL mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types NPL is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

HNSC, CCRCC, and PDAC are the cancer types where NPL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.701	<.001	8	view →
CCRCC	Male	All	−0.835	<.001	7	view →
PDAC	Female	All	+0.888	<.001	5	view →
COAD	Male	III,IV	−0.432	.022	2	view →
LUAD	Male	All	−0.221	.049	1	view →
LSCC	All	All	+0.188	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NPL–HNSC

Open the HNSC breakdown →