Across TCGA pan-cancer cohorts, NPIPB9 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NPIPB9’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where NPIPB9 RNA is repressed in tumor relative to normal tissue. In most cancer types NPIPB9 is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

THCA, KIRP, and READ are the cancer types where NPIPB9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPIPB9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.210	<.001	8	view →
KIRP	All	II,III,IV	+0.175	<.001	8	view →
READ	All	III,IV	−0.115	.030	2	view →
BRCA	All	III,IV	−0.064	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: NPIPB9 RNA expression & survival · all NPIPB9 data types