NPIPB3

Across TCGA cell cohorts, NPIPB3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible NPIPB3-associated genes across cancer lineages are RIT2, OR51Q1, and OR51J1. Each is linked with NPIPB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPIPB3-to-partner and partner-to-NPIPB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIT2 grouped by NPIPB3-low versus NPIPB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPIPB3→partner) and Y-score (partner→NPIPB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RIT2 →	+0.016	+4.415	.008	.007	3	2
PANCREAS	OR51Q1 →	+0.100	+5.000	<.001	.006	3	1
PANCREAS	OR51J1 →	+0.086	+5.000	<.001	.006	3	1
PANCREAS	OR2G6 →	+0.006	+5.000	<.001	.006	3	1
PANCREAS	MGAT4D →	+0.036	+5.000	<.001	.006	3	1
BREAST	LRRC10 →	+0.013	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

RIT2 by NPIPB3 expression — LARGE_INTESTINE

Explore this box plot interactively →