NPIPB3

Across TCGA pan-cancer cohorts, NPIPB3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NPIPB3 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher NPIPB3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NPIPB3 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCS show a favorable association.

BLCA, KIRC, and ACC are the cancer types where NPIPB3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.488	0.339	.003	128	view →
KIRC	DFS	Median	All	0.509	0.704	<.001	80	view →
ACC	DFS	Median	II,III,IV	0.258	0.696	<.001	42	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
PRAD	DFS	Quartile	All	0.646	0.837	<.001	30	view →
LGG	DFS	Median	All	0.285	0.474	<.001	29	view →
SKCM	DFS	Quartile	III,IV	0.640	0.379	.012	27	view →
CESC	DFS	Tertile	All	0.774	0.881	.009	24	view →
MESO	OS	Median	All	0.286	0.466	.009	20	view →
UVM	DFS	Median	III,IV	0.272	0.764	.005	20	view →
THCA	DFS	Tertile	II,III,IV	0.691	0.951	.016	18	view →
KICH	DFS	Tertile	III,IV	0.393	0.913	.023	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NPIPB3–BLCA (OS)

Open the BLCA breakdown →