NPHS2

Across TCGA patient cohorts, NPHS2 mutation is significantly associated with the RNA expression of many other genes, with 1,370 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPHS2-associated genes across cancer lineages are MMEL1, TMEM109, and SLC3A2. Each is linked with NPHS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPHS2-to-partner and partner-to-NPHS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMEL1 grouped by NPHS2-low versus NPHS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHS2→partner) and Y-score (partner→NPHS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MMEL1 →	-0.865	-3.896	<.001	<.001	3	3
LUSC	TMEM109 →	+0.444	+3.530	.005	.002	3	2
LUSC	SLC3A2 →	+0.776	+3.506	.001	.002	3	2
LUSC	MMP17 →	+0.675	+3.471	.008	.002	3	2
LUSC	COL15A1 →	+1.235	+3.471	.001	.002	3	2
LUSC	RNU6-458P →	+0.128	+3.993	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,370 associations by consensus.

MMEL1 by NPHS2 expression — UCEC

Explore this box plot interactively →