NPHS1

Across TCGA patient cohorts, NPHS1 mutation is significantly associated with the RNA expression of many other genes, with 7,071 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPHS1-associated genes across cancer lineages are ZNF274, BMS1P20, and LYSMD4. Each is linked with NPHS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPHS1-to-partner and partner-to-NPHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF274 grouped by NPHS1-low versus NPHS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHS1→partner) and Y-score (partner→NPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF274 →	+0.252	+1.364	.008	.003	3	4
LUSC	BMS1P20 →	+0.424	+2.105	<.001	.001	3	4
UCEC	LYSMD4 →	+0.345	+1.478	<.001	<.001	3	4
SKCM	NFATC2 →	-0.697	-1.280	.004	.004	3	3
SKCM	MICU1 →	+0.327	+1.478	<.001	.006	3	3
SKCM	GAR1 →	+0.258	+1.465	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,071 associations by consensus.

ZNF274 by NPHS1 expression — UCEC

Explore this box plot interactively →