NPHS1

Across TCGA pan-cancer cohorts, NPHS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of NPHS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NPHS1 RNA is repressed in tumor relative to normal tissue. In most cancer types NPHS1 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and KICH are the cancer types where NPHS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPHS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−4.938	<.001	12	view →
KIRP	Female	II,III,IV	−5.468	<.001	11	view →
KICH	Female	All	−4.271	<.001	7	view →
LIHC	All	All	+0.059	<.001	5	view →
BRCA	All	II,III,IV	+0.120	<.001	4	view →
THCA	All	All	−0.347	.003	3	view →
UCEC	All	IV	+0.609	.005	2	view →
LUAD	All	II,III,IV	+0.223	.037	2	view →
COAD	Female	IV	+0.210	.018	1	view →
CHOL	All	All	+0.150	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

NPHS1–KIRC

Open the KIRC breakdown →