NPHS1

Across TCGA patient cohorts, NPHS1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPHS1-associated genes across cancer lineages are eEF2, Rictor_pT1135, and EGFR_pY1068. Each is linked with NPHS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPHS1-to-partner and partner-to-NPHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by NPHS1-low versus NPHS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHS1→partner) and Y-score (partner→NPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.214	+2.132	.039	.008	3	4
UCEC	Rictor_pT1135 →	-0.072	-1.050	.010	.023	3	4
LUSC	EGFR_pY1068 →	-0.334	-1.575	.035	.035	3	3
LUAD	4E-BP1 →	+0.568	+3.012	<.001	.018	2	4
UCEC	PCNA →	+0.207	+1.722	<.001	<.001	3	3
UCEC	TFRC →	+0.460	+2.070	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

eEF2 by NPHS1 expression — SKCM

Explore this box plot interactively →