NPHS1

Across TCGA cell cohorts, NPHS1 mutation is significantly associated with the RNA expression of many other genes, with 231 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPHS1-associated genes across cancer lineages are KRTAP17-1, TFDP3, and C2CD5. Each is linked with NPHS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPHS1-to-partner and partner-to-NPHS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP17-1 grouped by NPHS1-low versus NPHS1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHS1→partner) and Y-score (partner→NPHS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRTAP17-1 →	+0.016	+5.369	<.001	.004	3	2
BLOOD_Leukemia	TFDP3 →	+0.007	+3.684	<.001	.004	3	2
LARGE_INTESTINE	C2CD5 →	+0.618	+3.743	.001	<.001	3	2
LARGE_INTESTINE	BMP2K →	+0.571	+3.743	.007	<.001	3	2
LARGE_INTESTINE	ETFA →	+0.692	+2.628	<.001	.002	3	2
LARGE_INTESTINE	PDSS2 →	+0.535	+3.169	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 231 associations by consensus.

KRTAP17-1 by NPHS1 expression — SOFT_TISSUE

Explore this box plot interactively →