NPHP4

Across TCGA pan-cancer cohorts, NPHP4 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated NPHP4 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NPHP4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NPHP4 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where NPHP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.803	1.000	.008	24	view →
HNSC	DFS	Median	All	0.775	0.373	.024	13	view →
LUAD	DFS	Quartile	II,III,IV	0.875	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

NPHP4–LSCC (OS)

Open the LSCC breakdown →