NPHP1

Across TCGA pan-cancer cohorts, NPHP1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated NPHP1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher NPHP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NPHP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

UCEC and LSCC are the cancer types where NPHP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.837	1.000	.017	6	view →
LSCC	OS	Median	III,IV	0.911	0.519	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

NPHP1–UCEC (OS)

Open the UCEC breakdown →