NPHP1

Across TCGA pan-cancer cohorts, NPHP1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of NPHP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NPHP1 RNA is repressed in tumor relative to normal tissue. In most cancer types NPHP1 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LUSC, and BLCA are the cancer types where NPHP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPHP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.691	<.001	9	view →
LUSC	Female	II,III,IV	−0.961	<.001	9	view →
BLCA	Male	III,IV	−0.658	.002	8	view →
LUAD	Female	II,III,IV	−0.590	<.001	7	view →
THCA	All	All	−0.351	<.001	7	view →
LIHC	All	All	+0.130	.004	4	view →
CHOL	Male	All	+1.575	<.001	3	view →
KIRP	All	IV	+0.530	.042	2	view →
READ	All	III,IV	+0.490	.021	2	view →
PRAD	All	All	−0.230	<.001	2	view →
BRCA	Female	All	−0.151	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

NPHP1–KICH

Open the KICH breakdown →