NPHP1

Across TCGA patient cohorts, NPHP1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPHP1-associated genes across cancer lineages are eIF4E, Shc_pY317, and ASNS. Each is linked with NPHP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPHP1-to-partner and partner-to-NPHP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NPHP1-low versus NPHP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP1→partner) and Y-score (partner→NPHP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.167	+1.938	.015	.001	3	2
UCEC	Shc_pY317 →	-0.148	-1.874	.003	.049	3	2
UCEC	ASNS →	+0.264	+1.415	.026	.043	3	2
UCEC	EGFR_pY1068 →	-0.261	-1.938	.001	.001	3	1
UCEC	EGFR →	-0.160	-2.674	.002	.005	3	1
UCEC	A-Raf_pS299 →	-0.100	-2.321	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by NPHP1 expression — UCEC

Explore this box plot interactively →