NPHP1

Across TCGA cell cohorts, NPHP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,842 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPHP1-associated GO terms across cancer lineages are Protein localization to ciliary transition zone, Protein localization to cilium, and Protein localization to non-motile cilium. Each is linked with NPHP1 in more than 18 cancer types. Because this analysis shows association rather than direction, both NPHP1-to-partner and partner-to-NPHP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to ciliary transition zone grouped by NPHP1-low versus NPHP1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP1→partner) and Y-score (partner→NPHP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Protein localization to ciliary transition zone →	+0.113	+1.439	.005	.001	3	19
BREAST	Protein localization to cilium →	+0.082	+1.271	<.001	<.001	3	19
STOMACH	Protein localization to non-motile cilium →	+0.084	+1.118	.005	.008	3	16
LARGE_INTESTINE	Protein localization to ciliary membrane →	+0.111	+1.031	<.001	<.001	3	13
LUNG_SCLC	Intraciliary anterograde transport →	+0.117	+0.970	<.001	.001	3	13
LUNG_NSCLC_LUAD	Non-motile cilium assembly →	+0.065	+0.760	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,842 associations by consensus.

Protein localization to ciliary transition zone by NPHP1 expression — LIVER

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