NPHP1

Across TCGA cell cohorts, NPHP1 mutation is significantly associated with the RNA expression of many other genes, with 639 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPHP1-associated genes across cancer lineages are SLCO1C1, DBX2, and DNASE2B. Each is linked with NPHP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NPHP1-to-partner and partner-to-NPHP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1C1 grouped by NPHP1-low versus NPHP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPHP1→partner) and Y-score (partner→NPHP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLCO1C1 →	+0.325	+2.450	.001	.007	3	3
LARGE_INTESTINE	DBX2 →	+0.007	+2.754	.001	.009	3	3
URINARY_TRACT	DNASE2B →	+0.223	+3.584	.002	.009	3	2
LARGE_INTESTINE	TECRL →	+0.008	+2.754	.002	.009	3	2
STOMACH	ZIC3 →	+0.686	+3.432	.003	.008	3	2
BLOOD_Leukemia	UCMA →	+0.065	+3.926	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 639 associations by consensus.

SLCO1C1 by NPHP1 expression — LARGE_INTESTINE

Explore this box plot interactively →