NPFFR2

Across TCGA cell cohorts, NPFFR2 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NPFFR2-associated genes across cancer lineages are NPAP1, PAGE3, and CLEC6A. Each is linked with NPFFR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPFFR2-to-partner and partner-to-NPFFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1 grouped by NPFFR2-low versus NPFFR2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPFFR2→partner) and Y-score (partner→NPFFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	NPAP1 →	+0.050	+4.867	.001	.009	3	2
BLOOD_Lymphoma	PAGE3 →	+0.105	+5.643	<.001	.002	3	2
SOFT_TISSUE	CLEC6A →	+0.039	+4.635	<.001	.003	3	1
BLOOD_Leukemia	AGXT2 →	+0.002	+3.984	<.001	.006	3	1
BLOOD_Leukemia	RHBDL3 →	+0.621	+3.302	<.001	.006	3	1
BLOOD_Leukemia	IL1RAPL2 →	+0.207	+2.774	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

NPAP1 by NPFFR2 expression — BLOOD_Lymphoma

Explore this box plot interactively →