NPFFR2

Across TCGA cell cohorts, NPFFR2 mutation is significantly associated with the mutation status of many other genes, with 2,612 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPFFR2-associated genes across cancer lineages are PCDHGA12, CNTN1, and ADAMTS7. Each is linked with NPFFR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both NPFFR2-to-partner and partner-to-NPFFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDHGA12 grouped by NPFFR2-low versus NPFFR2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPFFR2→partner) and Y-score (partner→NPFFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PCDHGA12 →	+2.756	+2.756	.006	.006	1	4
LUNG_NSCLC_LUAD	CNTN1 →	+2.493	+2.584	.009	.009	1	4
BLOOD_Leukemia	ADAMTS7 →	+2.341	+2.638	.009	.009	1	4
BREAST	NEK1 →	+4.857	+4.297	.009	.009	1	3
BREAST	CFAP47 →	+4.857	+4.297	.009	.009	1	3
SKIN	POU6F2 →	+4.357	+4.053	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,612 associations by consensus.

PCDHGA12 by NPFFR2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →