NPDC1

Across TCGA cell cohorts, NPDC1 mutation is significantly associated with the RNA expression of many other genes, with 215 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPDC1-associated genes across cancer lineages are OR9G1, SLC22A12, and GCAT. Each is linked with NPDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPDC1-to-partner and partner-to-NPDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR9G1 grouped by NPDC1-low versus NPDC1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPDC1→partner) and Y-score (partner→NPDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR9G1 →	+0.247	+4.874	<.001	.002	3	1
BLOOD_Leukemia	SLC22A12 →	+0.004	+4.539	<.001	.007	3	1
LARGE_INTESTINE	GCAT →	+1.230	+3.212	.003	.006	3	1
LARGE_INTESTINE	CENPM →	+0.866	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CBY1 →	+0.748	+3.330	<.001	.002	3	1
LARGE_INTESTINE	INTS10 →	+0.639	+3.212	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 215 associations by consensus.

OR9G1 by NPDC1 expression — BLOOD_Leukemia

Explore this box plot interactively →