NPDC1

Across TCGA pan-cancer cohorts, NPDC1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NPDC1 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NPDC1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NPDC1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

STAD, COAD, and UCEC are the cancer types where NPDC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Quartile	II,III,IV	0.712	0.503	<.001	79	view →
COAD	OS	Median	All	0.815	0.917	<.001	61	view →
UCEC	OS	Tertile	All	0.764	0.563	.001	46	view →
UCS	DFS	Median	II,III,IV	0.281	0.577	.011	36	view →
THCA	OS	Median	All	1.000	0.801	.002	32	view →
HNSC	OS	Quartile	All	0.691	0.840	.006	30	view →
PAAD	OS	Quartile	All	0.561	0.242	.006	25	view →
LUAD	DFS	Tertile	II,III,IV	0.608	0.729	.020	21	view →
OV	DFS	Median	All	0.576	0.501	.020	20	view →
UVM	DFS	Tertile	II,III,IV	0.312	0.634	.003	17	view →
PRAD	DFS	Quartile	All	0.822	0.932	.007	16	view →
KIRC	DFS	Tertile	IV	0.412	0.656	.018	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NPDC1–STAD (DFS)

Open the STAD breakdown →