NPC2

Across TCGA pan-cancer cohorts, NPC2 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of NPC2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where NPC2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NPC2 is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LSCC, and HNSC are the cancer types where NPC2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPC2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	−1.871	<.001	12	view →
LSCC	Male	II,III,IV	−1.109	<.001	9	view →
HNSC	All	II,III,IV	+0.273	<.001	8	view →
COAD	All	All	+0.211	<.001	7	view →
LUAD	Female	II,III,IV	+0.558	.013	3	view →
PDAC	All	All	+0.248	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

NPC2–CCRCC

Open the CCRCC breakdown →