NPC1L1

Across TCGA pan-cancer cohorts, NPC1L1 mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated NPC1L1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NPC1L1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NPC1L1 expression acts as an unfavorable survival marker.

PDAC are the cancer types where NPC1L1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.233	0.594	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

NPC1L1–PDAC (DFS)

Open the PDAC breakdown →