NPC1L1

Across TCGA patient cohorts, NPC1L1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,123 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible NPC1L1-associated GO terms across cancer lineages are Vitamin E metabolic process, Transcription elongation-coupled chromatin remodeling, and Regulation of mitochondrion organization. Each is linked with NPC1L1 in more than 16 cancer types. Because this analysis shows association rather than direction, both NPC1L1-to-partner and partner-to-NPC1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vitamin E metabolic process grouped by NPC1L1-low versus NPC1L1-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1L1→partner) and Y-score (partner→NPC1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Vitamin E metabolic process →	-0.179	-0.864	<.001	<.001	3	17
OV	Transcription elongation-coupled chromatin remodeling →	+0.040	+0.252	<.001	<.001	3	17
ESCA	Regulation of mitochondrion organization →	+0.037	+0.970	<.001	<.001	3	16
LAML	Regulation of DNA biosynthetic process →	+0.030	+0.280	<.001	<.001	3	16
GBM	Regulation of double-strand break repair →	+0.026	+0.238	<.001	<.001	3	16
GBM	DNA biosynthetic process →	+0.031	+0.382	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,123 associations by consensus.

Vitamin E metabolic process by NPC1L1 expression — UCS

Explore this box plot interactively →